Welcome to part eight of our blog series and your journey to a healthier metabolism, better energy levels, and a healthier body weight.

In the last post we learned that magnesium helps mitigate inflammation and calcification in your cells, thus protecting your mitochondria from these damaging factors.

Today we look at how magnesium is central to protecting your mitochondria and ensuring they can keep up with your energy demands, by mitigating another damaging factor in your cells: oxidative stress.  (You can find all the scientific literature for this post at iMag library’s metabolism section.)



Magnesium & Antioxidants Fight Oxidative Stress

Oxidative stress is the physical destruction of the cells that make up your body. It is caused by highly reactive oxygen-based molecules called free radicals. Free radicals are produced in your cells primarily under two different circumstances:

  1. As a natural byproduct of your mitochondria’s energy production.
  2. As a result of the toxic build-up of excess iron in your cells.

The human body has its own mechanism for both fighting and preventing excess free radicals and their resulting oxidative damage. It uses molecules called antioxidants, which neutralize free radicals. Magnesium plays a key role in producing two of your body’s most potent antioxidants:

  1. Glutathione: your most abundant antioxidant, made and recycled in your liver with the help of magnesium.
  2. Melatonin: sleep-inducing molecule with extremely protective antioxidant effects specifically for your brain and nerves. Melatonin is made from serotonin, and the conversion needs magnesium.

Melatonin doesn’t just help you fall asleep. It also protects your mitochondria from oxidative stress. Melatonin production requires magnesium!!!

The human body evolved this antioxidant system to deal with its natural production of free radicals that comes as a byproduct of mitochondrial energy production. Therefore, if all is well in your cells,  your mitochondria’s natural output of free radicals and the resulting oxidative stress, are comfortably dealt with by the cell’s production of antioxidants.

However, the second source of oxidative damage, can far outweight the capacity of your body’s innate antioxidant systems. This second more dangerous source of oxidative stress is cellular iron overload.


Iron Overload In Your Cells

Magnesium also prevents the toxic build-up of iron in your cells – which is a much more potent form of oxidative stress. This is because out of all the known atoms in the universe (which can be found on the periodic table of elements), iron is the single most stimulatory atom of oxidative stress! This is because excess, unbound iron inside your cells has a very strong predisposition to create the most damaging free radical in the human body; the hydroxyl radical.

(Iron’s creation of the damaging hydroxyl radical is famously known (in the scientific worlds anyways) as the fenton reaction.)

Excess, unbound iron in your cells stimulates the creation of the body’s most damaging free-radical. This hydroxyl radical causes oxidative damage to your mitochondria.

Therefore it’s critical to prevent the buildup of excess iron in your cells, otherwise they can seriously damage and deteriorate your mitochondira.


Magnesium Prevents Iron Overload & Oxidative Stress

Magnesium prevents excess iron buildup in cells via its role in the production and recycling of the enzyme ceruloplasmin:

Ceruloplasmin is a molecule that prevents iron from building up in your cells, by instead keeping the iron flowing in your blood where it’s supposed to be.  Ceruloplasmin does this by loading iron onto your blood’s oxygen-carrying molecules, where it belongs.  

Low magnesium = low ceruloplasmin which causes excess iron in your cells, and less iron in our blood.

Not only does this increase the amount of hydroxyl free radicals that damage your mitochondria and reduce your energy levels, but it does so in a deceptive manner:

This bodily state of cellular iron overload actually tricks most doctors. This is because of several reasons:

First, doctors only test for iron in your blood, and NOT your cells. So it may end up showing that you’re LOW on iron when really you have too much, but oin the wrong place (in your cells!).

Second, doctors not test for ceruloplasmin since it is not recommended by the establishment. The hard truth is that most of them don’t even know what this critical enzyme is! If you don’t believ this, just ask your doctor?

Third, scientists have long ago concluded that the medical establishment tells doctors to use an innaccurate form of magnesium testing, which usually fails to spot magnesium deficiency. (Learn more here.)

All three of these factors combined make it nearly impossible for a doctor to figure out when a person is suffering from cellular iron overload and the resulting oxidative damage to their mitochondria. 



Oxidative stress causes cellular and mitochondrial damage. As you now know, if your mitochondria are damaged, your body’s energy production drops and you may experience fatigue as well as just a drop in your overall quality of life. If you’re suffering from low energy levels, there is a very good chance you are magnesium-deficient, as it has now become a silent epidemic that affects over 90% of people.

To learn about why it’s so common, and how you can test your magnesium, read our magnesium basics series.  

See why so many people are using iMag natural magnesium to restore their magnesium levels and improve their energy levels by helping to mitigate oxidative damage to their mitochondria cellular energy factories!

We’ll see you in the next post where we summarize our healthy metabolism journey, along with your metabolism’s most vital nutrient!

Related Posts:

Magnesium For Energy & Fat Loss Part 7: Magnesium Protects Your Energy Factories

Magnesium For Energy & Fat Loss Part 9: Fat Loss & Energy DEPEND on Magnesium

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Anything not referenced/cited here can be found on iMag Library (magnesiumhealth.org). This is our sister website that we created for you with all the scientific literature about magnesium and the human body.

(We assume no responsibility and/or credit for any of the graphics used in this post. All credit goes to the various and individual creators of graphic and visual content.)